Fig. 2.13 Importance of proper protein structure for function. Correct structure of the protein enzyme is necessary to help molecules (i.e., substrates) react. Cofactors and coenzymes (e.g., minerals, vitamins) bind, helping enzymes work effectively. (See also: http://www.phschool.com/science/biology_place/labbench/lab2/ph.html) (Sources of images below. Used with permission.)

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Description Name: Microbiology ID: e42bd376-624b-4c0f-972f-e0c57998e765@4.4 Language: English Summary: Subjects: Science and Technology Keywords: Print Style: License: Creative commons Attribution License (by 4.0) Authors: OpenStax Microbiology Copyright Holders: OpenStax Microbiology Publishers: OpenStax Microbiology Latest Version: 4.4 First Publication Date: Oct 17, 2016 Latest Revision: Nov 11, 2016 Last Edited By:

Description English: Enzyme changes shape by induced fit upon substrate binding to form enzyme-substrate complex. Hexokinase has a large induced fit motion that closes over the substrates adenosine triphosphate and xylose. Binding sites in blue, substrates in black and Mg²⁺ cofactor in yellow. (PDB: 2E2N, 2E2Q)

Enzyme changes shape by induced fit upon substrate binding to form enzyme-substrate complex. Hexokinase has a large induced fit motion that closes over the substrates adenosine triphosphate and xylose. Binding sites in blue, substrates in black and Mg²⁺ cofactor in yellow.